The compounds prevent the growth of smooth muscle cells that can clog the affected area, but they can also prevent the growth of helpful endothelial cells that, in addition to the drugs, are critical to preventing LST. Thiruppathi and Mani set out to find a way to address this problem.Every year, more than 1 million people in the U.S. who have suffered heart attacks or chest pain from blocked arteries have little mesh tubes called stents inserted into their blood vessels to prop them open. The procedure has saved many lives, but it still has potentially deadly downsides. Now scientists are reporting in the ACS journalLangmuir that coating stents with vitamin C could lower the implants' risks even further.
Previous research has shown that vitamin C could be a good alternative or addition to the drugs currently used to coat stents. The essential nutrient inhibits smooth muscle cells and encourages endothelial cells - just the traits the scientists were looking for. So they figured out a way to successfully coat a common stent material with vitamin C so that it would release the nutrient slowly over time. They concluded that this technique could be useful for making stents and other implantable medical devices safer.
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ARTICLE #1 FOR IMMEDIATE RELEASE
"Vitamin-C Delivery from CoCr alloy Surfaces Using Polymer-Free and Polymer-Based Platforms For Cardiovascular Stent Applications"
Gopinath Mani, Ph.D.
Biomedical Engineering Program
The University of South Dakota
4800 N. Career Ave.
Sioux Falls, SD 57107
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