Stem Cell Issues
Packaging Stem Cells in Capsules for Heart Therapy
Oct 11, 2013 - 10:31:46 AM
Cardiology researchers at Emory have a solution for this problem. The researchers package stem cells in a capsule made of alginate, a gel-like substance. Once packaged, the cells stay put, releasing their healing factors over time.
Researchers used encapsulated mesenchymal stem cells to form a "patch" that was applied to the hearts of rats after a heart attack. Compared with animals treated with naked cells (or with nothing), rats treated with the capsule patches displayed increased heart function, reduced scar size and more growth of new blood vessels a month later. In addition, many more of the encapsulated cells stayed alive.
"This approach appears to be an effective way to increase cell retention and survival in the context of cardiac cell therapy," says W. Robert Taylor, MD, professor of medicine and director of the cardiology division at Emory University School of Medicine and professor in the Wallace H. Coulter Department of Biomedical Engineering at Georgia Tech and Emory. "It may be a strategy applicable to many cell types for regenerative therapy in cardiovascular disease."
The results were published Oct. 10 in the Journal of the American Heart Association. The first author is cardiovascular research fellow Rebecca Levit, MD. She and her colleagues collaborated with the laboratory of Andres Garcia, PhD, in the Coulter Department of Biomedical Engineering, in developing the patch used to apply the encapsulated cells.
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