Advanced Search
Current and Breaking News for Professionals, Consumers and Media



Click here to learn how to advertise on this site and for ad rates.

opiods Author: Staff Editor Last Updated: Feb 13, 2018 - 11:41:10 AM



Opioid Use Increases Risk of Serious Infections

By Staff Editor
Feb 13, 2018 - 11:34:44 AM



Email Newsletter icon, E-mail Newsletter icon, Email List icon, E-mail List icon Sign up for our Ezine
For Email Marketing you can trust


Email this article
 Printer friendly page

(HealthNewsDigest.com) - Opioid users have a significantly increased risk of infections severe enough to require treatment at the hospital, such as pneumonia and meningitis, as compared to people who don’t use opioids.

The Vanderbilt University Medical Center study, released today by the Annals of Internal Medicine, found that people who use opioids have a 1.62 times higher risk of invasive pneumococcal diseases.

Invasive pneumococcal diseases are serious infections caused by the Streptococcus pneumoniae bacteria, with mortality ranging from 5 to 20 percent. These invasive diseases include a range of illnesses such as meningitis, bacteremia and invasive pneumonia.

“The association between opioid use and the risk of invasive pneumococcal diseases was strongest for opioids used at high doses, those classified as high potency and long-acting, which would be the extended release or controlled release formulations,” said lead author Andrew Wiese, PhD, MPH, postdoctoral research fellow in the Department of Health Policy at Vanderbilt University School of Medicine.

“We also found that opioids previously described as immunosuppressive in prior experimental studies conducted in animals had the strongest association with invasive pneumococcal diseases in humans,” he said.

Wiese and colleagues studied Tennessee Medicaid Data to measure daily prescription opioid exposure for each study individual and combined that information with Active Bacterial Core (ABC) surveillance system data, which is a VUMC laboratory and population-based surveillance system conducted in partnership with the Tennessee Department of Health and the Centers for Disease Control and Prevention to monitor invasive infectious diseases in Tennessee.

“A unique feature of the study is the use of laboratory-confirmed infections as study outcomes. The sources of data allowed us to reconstruct and compare the history of opioid exposures in those subjects with and without invasive pneumococcal diseases,” said Carlos Grijalva, MD, MPH associate professor of Health Policy and senior author of the study.

The increase in opioid use in the U.S. over the past several years has led to an increased interest toward well-known and also previously under-recognized adverse effects associated with opioid use.

“Previous studies conducted in animal models had demonstrated that certain opioids can cause immunosuppression and render experimental animals susceptible to infections. However, the clinical implications of those observations in humans were unclear” said Grijalva.

In an accompanying editorial, Sascha Dublin, MD, and Michael von Korff, ScD, from the Kaiser Permanente Washington Health Research Institute indicate that this research provides “…cautionary evidence of a higher infection risk with prescription opioid use, suggesting the need for prudent steps to protect patients...” They further emphasize the need for judicious prescribing of opioids and conclude that “opioid prescribing should be consistently cautious and closely monitored among all patients, especially those at increased risk for infections, who may be particularly susceptible to harm.”

“The findings from our study are clinically relevant. Providers should consider these results when making pain management decisions,” added Wiese.

Other Vanderbilt faculty and staff members that contributed to the study were Marie Griffin, MD, MPH, William Schaffner, MD, C. Michael Stein, MB, ChB, Robert Greevy, PhD and Edward Mitchel, Jr, MS.

This research was supported by grants from the National Institutes of Health – National Institute on Aging [R03-AG042981 and R01-AG043471] and TL1TR000447.

Opioid users have a significantly increased risk of infections severe enough to require treatment at the hospital, such as pneumonia and meningitis, as compared to people who don’t use opioids.

The Vanderbilt University Medical Center study, released today by the Annals of Internal Medicine, found that people who use opioids have a 1.62 times higher risk of invasive pneumococcal diseases.

Invasive pneumococcal diseases are serious infections caused by the Streptococcus pneumoniae bacteria, with mortality ranging from 5 to 20 percent. These invasive diseases include a range of illnesses such as meningitis, bacteremia and invasive pneumonia.

“The association between opioid use and the risk of invasive pneumococcal diseases was strongest for opioids used at high doses, those classified as high potency and long-acting, which would be the extended release or controlled release formulations,” said lead author Andrew Wiese, PhD, MPH, postdoctoral research fellow in the Department of Health Policy at Vanderbilt University School of Medicine.

“We also found that opioids previously described as immunosuppressive in prior experimental studies conducted in animals had the strongest association with invasive pneumococcal diseases in humans,” he said.

Wiese and colleagues studied Tennessee Medicaid Data to measure daily prescription opioid exposure for each study individual and combined that information with Active Bacterial Core (ABC) surveillance system data, which is a VUMC laboratory and population-based surveillance system conducted in partnership with the Tennessee Department of Health and the Centers for Disease Control and Prevention to monitor invasive infectious diseases in Tennessee.

“A unique feature of the study is the use of laboratory-confirmed infections as study outcomes. The sources of data allowed us to reconstruct and compare the history of opioid exposures in those subjects with and without invasive pneumococcal diseases,” said Carlos Grijalva, MD, MPH associate professor of Health Policy and senior author of the study.

The increase in opioid use in the U.S. over the past several years has led to an increased interest toward well-known and also previously under-recognized adverse effects associated with opioid use.

“Previous studies conducted in animal models had demonstrated that certain opioids can cause immunosuppression and render experimental animals susceptible to infections. However, the clinical implications of those observations in humans were unclear” said Grijalva.

In an accompanying editorial, Sascha Dublin, MD, and Michael von Korff, ScD, from the Kaiser Permanente Washington Health Research Institute indicate that this research provides “…cautionary evidence of a higher infection risk with prescription opioid use, suggesting the need for prudent steps to protect patients...” They further emphasize the need for judicious prescribing of opioids and conclude that “opioid prescribing should be consistently cautious and closely monitored among all patients, especially those at increased risk for infections, who may be particularly susceptible to harm.”

“The findings from our study are clinically relevant. Providers should consider these results when making pain management decisions,” added Wiese.

Other Vanderbilt faculty and staff members that contributed to the study were Marie Griffin, MD, MPH, William Schaffner, MD, C. Michael Stein, MB, ChB, Robert Greevy, PhD and Edward Mitchel, Jr, MS.

This research was supported by grants from the National Institutes of Health – National Institute on Aging [R03-AG042981 and R01-AG043471] and TL1TR000447.

###



Top of Page

HealthNewsDigest.com

opiods
Latest Headlines


+ Opioid Use Increases Risk of Serious Infections
+ Low-Tech, Low-Cost Test Strips Show Promise for Reducing Fentanyl Overdoses
+ Train 30 Police Departments on Using Narcan to Combat Opioid Crisis
+ 1 in 7 Lung Surgery Patients at Risk for Opioid Dependence
+ Surgery Patients in Enhanced Recovery Program Leave Hospital Sooner, Take Fewer Opioids
+ Pain Care Outcomes Unaffected by Opioid Dose Reductions
+ Opioids Often Not the Answer to Post-Surgery Pain
+ Length of Opioid Prescription, Number of Refills Spell Highest Risk for Misuse After Surgery
+ Default Setting in Electronic Medical Records “Nudged” Emergency Department Physicians to Limit Opioid Prescriptions to 10 Tablets
+ Practice Guidelines for Using Laboratory Drug Tests to Combat Opioid Addiction, Overdoses



Contact Us | Job Listings | Help | Site Map | About Us
Advertising Information | HND Press Release | Submit Information | Disclaimer

Site hosted by Sanchez Productions