The pathway from chronic inflammation to disease is very complex. It starts with our immune system. When you are injured or exposed to an infection, your innate immunity defense system becomes the body's first line of defense. This immune defense is usually limited in both time and potency. If the innate immune defense system fails, your adaptive immune system kicks in. Unlike the innate system, the adaptive immune system produces memory cells that can both recognize and react again when faced with a repetitive invader.
In most instances the two immune systems work together to control infections and heal injuries but sometimes the mechanism of the two systems becomes overwhelmed and prolonged, chronic inflammation can set in. Chronic inflammation can damage body cells and set the stage for serious disease. It is believed that chronic inflammation can cause kidney disease, irritable bowel disease, type 2 diabetes, heart disease and cancer.
Though the factors that trigger various diseases may be different, the connection between chronic inflammation and disease follows the same process. Cytokines are small protein particles that act as a signaling system for inflammation. Specific cytokines promote inflammation to create healing and others turn off inflammation when the problem is repaired. An imbalance in the activity between pro-inflammatory cytokines and anti-inflammatory cytokines leads to chronic inflammation and can start the disease process.
Weighing too much can promote chronic inflammation. Belly fat stimulates pro-inflammatory cytokines leading to chronic low-grade inflammation. This situation can increase the risk for type 2 diabetes. People with type 2 diabetes have higher levels of pro-inflammatory and lower levels of anti-inflammatory cytokines. A distorted inflammatory response may also be responsible to plaque development in heart disease and tumor growth in cancer.
Food can play a role by both promoting inflammation and combating inflammation.
If you are someone who is at risk for diabetes, high cholesterol, hypertension, and heart disease or if cancer runs in the family, eating a diet rich in anti-inflammatory foods may be another way to decrease your risk and improve your health.
© NRH Nutrition Consultants, Inc.
The Diabetes Counter, 5th Ed., 2014
The Fat and Cholesterol Counter, 2014
The Most Complete Food Counter, 3rd ed., 2013
The Calorie Counter, 6th Ed., 2013
The Complete Food Counter, 4th ed., 2012
The Protein Counter, 3rd Ed., 2011
The Ultimate Carbohydrate Counter, 3rd Ed., 2010
The Healthy Wholefoods Counter, 2008
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