The findings are published in the journal Parkinsonism and Related Disorders.
Parkinson's disease is a progressive neurodegenerative disorder that affects more than 1 million Americans. Each year, about 60,000 Americans are newly diagnosed with Parkinson's disease. Parkinson's patients develop progressive disability over time, despite the best pharmacological and surgical management. Therefore, complementary approaches that can maximize functional ability and improve quality of life are important.
In this pilot study, 31 patients with Parkinson's disease were randomly assigned to an "early start group" or a "delayed start group" for a rigorous formal group exercise program that met for one hour, three days a week. The early start group exercised for a total of 48 weeks, while the delayed start group exercised only the last 24 weeks. One patient dropped out of the study.
"Our findings demonstrate that long-term group exercise programs are feasible in the Parkinson's disease population. Patients enjoyed exercising, and they stayed with the program that included cardiovascular and resistance training," said principal investigator Dr. Ariane Park, a movement disorder neurologist at the Madden Center for Parkinson's Disease and Related Disorders at Ohio State's Wexner Medical Center.
"Our study also showed that earlier participation in a group exercise program significantly improved symptoms of depression compared to the delayed start group, and this is important because often mood can be more debilitating than motor symptoms," Park said.
More than 50 percent of patients with Parkinson's disease suffer from depression, which is why it is important to help patients find new ways to cope and improve their symptoms, said Park, who also is a researcher in Ohio State's Neuroscience Program.
Researchers had also hoped to show that exercise could slow the progression of the disease, but the study did not provide strong evidence of any ‘neuroprotective' effect on motor function, possibly because of the small sample size, Park said.
"We recommend exercise to all of our Parkinson's patients. Currently, there is no consensus on a standardized physical exercise regimen with regard to type, frequency and intensity. The literature supports that any routine that improves physical fitness is good for Parkinson's disease - and that can include walking, swimming, tai chi or even dancing," Park said. "We just want patients to move on a regular basis. Not only will they move better, but they will feel better."
Other researchers include Xiaobai Li, Allison Wehr, Andrea Malone, Alicia Rendon, David Zid and Jackie Russell.
The study was funded by the Madden Center Development Fund; OSU Parkinson's Disease Our Goal is a Cure Fund; Columbus branch of the National Parkinson's Foundation and OSU Center for Clinical and Translational Science CTSA Grant number UL1TR000090.
The Ohio State University Wexner Medical Center Neuroscience Program features 160 researchers and clinicians collaborating in neurology, neurosurgery, physical medicine and rehabilitation, psychiatry and neuroscience research to create better methods of prevention, detection and treatment for patients.
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