Advanced Search
Current and Breaking News for Professionals, Consumers and Media

Click here to learn how to advertise on this site and for ad rates.

Depression Author: Staff Editor Last Updated: Sep 8, 2017 - 11:54:44 AM

Depression Treatment May Be Improving

By Staff Editor
Sep 8, 2017 - 11:51:24 AM

Email Newsletter icon, E-mail Newsletter icon, Email List icon, E-mail List icon Sign up for our Ezine
For Email Marketing you can trust

Email this article
 Printer friendly page

( - In a new study published in the journal Cell Reports, researchers associated with the Tulane Brain Institute say they have moved a step closer to improving treatment for chronic depression.

The study involves deleting a subunit of the NMDA receptor complex in a specific type of brain cell, in an effort to understand exactly how drugs like ketamine provide antidepressant relief.

Ketamine, which interferes with the NMDA receptor, produces rapid antidepressant actions in treatment-resistant patients. However, because of its hallucinatory side effects, it has not been approved for treatment of depression.

“To improve treatment for depression, it is important to identify how ketamine activates specific brain ‘circuits’ to alter behavioral states and then work on targeting those circuits,” said Benjamin Hall, a research associate professor in the Tulane Department of Cell and Molecular Biology.

Hall and graduate student Oliver H. Miller, the lead author of the paper, embarked on the study five years ago with a $1.8 million grant from the National Institute of Mental Health. Hall is now based at Roche Innovation Center in Basel, Switzerland, and Miller is at the University of California at San Francisco. Researchers at the University of Strasbourg also collaborated on the study.

In the study, researchers showed that deletion of a specific subunit of the NMDA receptor complex, called GluN2B – located in a region of the brain known as the prefrontal cortex (PFC) - enhances the connection between that part of the cortex and the thalamus to change behavior in mice.

These experiments confirm an important role for NMDA receptors and the PFC in regulating mood-related behaviors but also directly implicate information transfer from the medial dorsal thalamus to the PFC in controlling these behaviors.

“This study lays the groundwork for finding ways to pharmacologically activate this pathway in humans to treat severe depression,” Hall said.


Top of Page

Latest Headlines

+ Why Pediatricians' Role in Treating Depression in Adolescents is Critical
+ Opioid Cessation May Be More Successful When Depression Is Treated
+ ‘Depression Education’ Effective For Some Teens
+ People Who Sleep Less Than 8 Hours a Night More Likely to Suffer From Depression, Anxiety
+ Tips For Coping With Depression While Traveling
+ Combinations of Certain Personality Traits May Guard Against Depression and Anxiety
+ Probiotics Studies Widening, from Skincare to Depression Treatments
+ Depressed with a Chronic Disease? Consider Alternative Therapies
+ Disaster Makes People with Depression Less Healthy
+ Indoor Tanning Dependency Common in Young Women, Especially In Those With Depression

Contact Us | Job Listings | Help | Site Map | About Us
Advertising Information | HND Press Release | Submit Information | Disclaimer

Site hosted by Sanchez Productions