Immune System 'Overdrive' in Pregnant Women Puts Male Offspring at Risk for Adult Brain Disorders
Feb 6, 2014 - 2:12:31 PM
In a report on the research published online last week in the journal Brain, Behavior and Immunity, the investigators say that the hippocampus - the part of the brain responsible for memory and spatial navigation - was smaller over the long term in the male offspring exposed to the overactive immune system in the womb. The males also had fewer nerve cells in their brains, and their brains contained a type of immune cell that shouldn't be present there.
"Our research suggests that in mice, males may be more vulnerable to the effects of maternal inflammation than females, and the impact may be lifelong," says study leader Irina Burd, M.D., Ph.D., an assistant professor of gynecology and obstetrics and neurology at the Johns Hopkins University School of Medicine and director of the Integrated Research Center for Fetal Medicine. "Now we wonder if this could explain why more males have diseases such as autism and schizophrenia, which appear to have neurobiological causes."
For the study, researchers sought to mimic the effects of a maternal infection or other condition that causes inflammation in a pregnant mother. This type of inflammation occurring between 18 and 32 weeks of gestation in humans has been linked to preterm birth, and it may be responsible for an imbalance of immune cells in the brain of the offspring and even death of nerve cells in the brains of those children. Burd and her colleagues used a mouse model to study what happens to the brains of those offspring as they age into adulthood to see if the effects persisted.
One group of pregnant mice got saline injections into the womb, while another group got injections of lipopolysaccharide, a toxin meant to generate the kind of inflammatory effects of E. coli bacteria without the presence of the germ itself.
Soon after birth, the lipopolysaccharide group showed poor motor skills and behavioral issues such as hyperactivity. At 60 days post-weaning - the equivalent of mouse adulthood - the lipopolysaccharide mice could walk well but were still hyperactive, suggesting the motor problems were resolved - possibly through some type of rewiring of the brain - but the behavioral problems were not.
"All this time later, something was still going on in their brains," Burd says.
The sex-specific differences - the smaller hippocampus, the presence of fewer nerve cells, the existence of immune system macrophages in places they shouldn't be - were also found in adulthood.
Chronic inflammation, Burd says, may play a role in keeping the hippocampus small, potentially because it inhibits proper brain development. But why males and females respond differently to the same stressor in utero remains a question.
Unraveling the sex-based mechanisms underlying the response to maternal inflammation could provide critical knowledge necessary to develop interventions and potentially new drug therapies, she says.
Other Johns Hopkins researchers involved in the study include Tahani Dada, M.D.; Jason Rosenzweig, Ph.D.; Mofeedah Al Shammary, M.D.; Wance Firdaus, Ph.D.; Shorouq Al Rebh, M.D.; Talaibek Borbiev, Ph.D.; Aylin Tekes, M.D.; Jiangyang Zhang, Ph.D.; Eman Alqahtani, M.D.; Susumu Mori, Ph.D.; Mikhail V. Pletnikov, M.D., Ph.D.; and Michael V. Johnston, M.D.
The research was supported by the Aramco Services Company Fellowship Fund, the National Institutes of Health's Eunice Kennedy Shriver National Institute of Child Health and Human Development (K08HD073315), National Institute of Neurological Disorders and Stroke (NS28208), National Institute of Biomedical Imaging and Bioengineering (R01 EB003543) and the Johns Hopkins Brain Science Institute.
For more information about Burd's lab, click here.
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