The report, a comparative effectiveness review prepared for AHRQ's Effective Health Care Program by the Minnesota Evidence-based Practice Center, was published today in Annals of Internal Medicine. The full report and summary publications for consumers and clinicians are available at www.effectivehealthcare.ahrq.gov.
"Urinary incontinence can affect women in a variety of ways, including physically, psychologically and socially--and some of these impacts can be severe," said AHRQ Director Carolyn M. Clancy, M.D. "This new report will help women and their clinicians work together to find the best treatment option based on each patient's individual circumstances."
Urinary incontinence is extremely common in adult women, affecting approximately 25 percent of young women, up to 57 percent of middle-aged and postmenopausal women, and approximately 75 percent of older women in nursing homes. The condition can impose significant, potentially debilitating lifestyle restrictions. The cost of incontinence care in the United States averaged $19.5 billion in 2004, and by one estimate the annualized cost of women's nursing home admissions due to urinary incontinence was $3 billion. Six percent of nursing home admissions of older women are attributable to urinary incontinence.
Researchers concentrated on two kinds of incontinence: stress incontinence, or the inability to retain urine during coughing or sneezing; and urgency incontinence, which is an involuntary loss of urine associated with the sensation of a sudden, compelling urge to urinate that is difficult to defer. Both types usually occur when the urinary sphincter fails, often as a result of weak pelvic floor muscles, which support the uterus, bladder, and other pelvic organs.
Exercises to strengthen the pelvic floor muscles, similar to Kegel exercises, were found to be effective in increasing women's ability to hold their urine. Pelvic floor muscle training combined with bladder training improved mixed (stress and urgency) incontinence, the report found. Estrogen treatment was found to be effective in treating stress incontinence, but with some side effects. Another drug treatment, the antidepressant duloxetine, was not found to be effective, while carrying high risk of side effects.
Overall, the report found that the drugs reviewed showed similar effectiveness. However, with some drugs, more women discontinued treatment due to bothersome side effects. The report provides comprehensive information about side effects with each drug to help clinicians and patients choose treatments with the most benefits and least harms.
Researchers said that while there is much evidence on clinical measures for treatment of urinary incontinence, such as grams of urine lost, there are fewer measures of quality of life related to the condition and its treatments.
The report, Nonsurgical Treatments for Urinary Incontinence in Adult Women: Diagnosis and Comparative Effectiveness, is the latest comparative effectiveness review from AHRQ's Effective Health Care Program. The Effective Health Care Program helps patients, doctors, nurses, pharmacists and others choose the most effective treatments by sponsoring the development of evidence reports and technology assessments to assist public- and private-sector organizations in their efforts to improve the quality of health care in the United States. More information about the program can be found at www.effectivehealthcare.ahrq.gov.
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