The results, available online and published in the December issue of the Annals of Thoracic Surgery, provide much-needed data on patients 65 years and older that could guide future treatment recommendations for people with severe heart disease.
"It is widely accepted that mitral repair is the treatment of choice for people with severe heart disease caused by a leaking mitral valve, and it can restore life expectancy to normal," said Vinay Badhwar, M.D., associate professor of surgery at Pitt, co-director of the UPMC Center for Mitral Valve Disease and chief of cardiac surgery at UPMC Presbyterian hospital. "However, in older patients, current guidelines recommend initial medical management of the disease, delaying surgery until symptoms are very advanced. In some cases, delays in surgery can lower quality of life and make the eventual surgery riskier as the patient's health further deteriorates."
Dr. Badhwar and his team collected national data on 14,604 people age 65 and older who had mitral valve repair operations between 1991 and 2007. They examined rates of mortality, re-operation and readmissions for heart failure, bleeding and stroke.
Less than 3 percent of the patients, who had an average age of 73, died during surgery. The five-year survival rate was nearly 75 percent. One of their most important findings was that following mitral repair, the 10-year survival rate was more than 57 percent, comparable to the average age-matched U.S. population without heart disease. Five years after surgery, 3.7 percent of the patients had to have another mitral valve operation; 18.4 percent experienced heart failure; 7.2 percent were readmitted for bleeding; and 7.7 percent had a stroke. Readmissions were most common in patients that presented to surgery late in their illness from mitral valve disease.
"Our data show that not only is mitral valve repair a safe option for elderly patients because of its excellent early outcomes and the low incidence of late stroke and bleeding, but it also is a well-tolerated and lasting solution for the treatment of severe heart disease," Dr. Badhwar said. "This information will improve medical guidelines to emphasize the importance of timely referral of older patients for mitral valve surgery."
The mitral valve lies between the atria and ventricles of the heart and helps control blood flow. When it malfunctions, blood doesn't flow the way it should, which can lead to congestive heart failure. Symptoms include shortness of breath and decreased ability to endure physical activity.
Benefits of promptly repairing the mitral valve include preservation of heart function, leading to an improved quality of life; less need for re-operation; lower operative mortality; and improved long-term survival. It also can lead to a lower likelihood of readmission for heart failure, a globally important health care issue as costs associated with readmissions continue to climb.
"The baby boomer generation will be entirely over age 65 by 2030, making it critical that we research and promote therapies that can influence long-term, hospital-free survival of older people," Dr. Badhwar said. "Such measures will have lasting health care implications and allow hospitals to best manage their resources."
Collaborators on this research included Eric D. Peterson, M.D., M.P.H., J. Matthew Brennan, M.D., M.P.H., Sean M. O'Brien, Ph.D., Xia He, M.S., and Rachel S. Dokholyan, M.P.H., all of Duke University; Jeffrey P. Jacobs, M.D., University of South Florida College of Medicine; Steven F. Bolling, M.D., University of Michigan; David M. Shahian, M.D., Harvard University; Fredrick L. Grover, M.D., University of Colorado; Fred H. Edwards, M.D., University of Florida; and James S. Gammie, M.D., University of Maryland.
This work was supported by The Society of Thoracic Surgeons Research Center through the Adult National Cardiac Database.
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About the University of Pittsburgh School of Medicine
As one of the nation's leading academic centers for biomedical research, the University of Pittsburgh School of Medicine integrates advanced technology with basic science across a broad range of disciplines in a continuous quest to harness the power of new knowledge and improve the human condition. Driven mainly by the School of Medicine and its affiliates, Pitt has ranked among the top 10 recipients of funding from the National Institutes of Health since 1998. In rankings recently released by the National Science Foundation, Pitt ranked fifth among all American universities in total federal science and engineering research and development support.
Likewise, the School of Medicine is equally committed to advancing the quality and strength of its medical and graduate education programs, for which it is recognized as an innovative leader, and to training highly skilled, compassionate clinicians and creative scientists well-equipped to engage in world-class research. The School of Medicine is the academic partner of UPMC, which has collaborated with the University to raise the standard of medical excellence in Pittsburgh and to position health care as a driving force behind the region's economy. For more information about the School of Medicine, seewww.medschool.pitt.edu.
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