Advanced Search
Current and Breaking News for Professionals, Consumers and Media



Click here to learn how to advertise on this site and for ad rates.

Research Author: Staff Editor Last Updated: Dec 18, 2013 - 3:00:41 PM



deCODE Genetics Uncovers Impact of Mutations in The Human Genome on Cognitive Ability

By Staff Editor
Dec 18, 2013 - 2:56:41 PM



Email Newsletter icon, E-mail Newsletter icon, Email List icon, E-mail List icon Sign up for our Ezine
For Email Marketing you can trust


Email this article
 Printer friendly page

(HealthNewsDigest.com) - REYKJAVIK, Iceland, Dec. 18, 2013  -- deCODE genetics, a global leader in analyzing and understanding the human genome, reported today in the journal Nature that mutations associated with an increased risk of schizophrenia and autism also affect cognition in individuals without the disease or intellectual disability. The research suggests that cognitive abnormalities are fundamental in schizophrenia, yet outward signs of the disease only manifest in a subset of carriers of the mutations.

"This study provides one of the first footholds into biochemical understanding of humans' unique cognitive abilities," said study lead author Kari Stefansson, M.D., Dr. Med., CEO of deCODE genetics. "At the same time, these results raise important questions as to why certain mutations impact some individuals more dramatically than others."

Certain copy number variants (CNVs), one type of mutation, have been previously identified as strong risk factors for schizophrenia and autism, neuropsychiatric diseases which affect cognition. Researchers sought to understand what, if any, impact these CNVs may have on cognitive ability in disease-free carriers.

They administered neuropsychiatric tests to 1,268 individuals across four groups (schizophrenia patients, control carriers of neuropsychiatric CNVs, control carriers of other CNVs and population controls), and found that carriers of CNVs that predispose to neuropsychiatric disease have cognitive abilities between people without the CNVs and people with schizophrenia.

"Our results suggest that neuropsychiatric CNVs can be used as an instrument for further study of the cognitive abnormalities that characterize schizophrenia, because whether or not an individual develops this disease is likely related to the expression of these genes," said Stefansson. "The findings also provide insight into which cognitive abilities put individuals at risk of developing schizophrenia and demonstrate that control carriers provide an opportunity to study cognitive abnormalities without the confounding effects of psychosis or medication."

About deCODE

Headquartered in Reykjavik, Iceland, deCODE genetics is a global leader in analyzing and understanding the human genome. Using its unique expertise and population resources, deCODE has discovered genetic risk factors for dozens of common diseases ranging from cardiovascular disease to cancer. deCODE genetics is a subsidiary of Amgen. deCODE's corporate information can be found at http://www.decode.com.

###
For advertising and promotion on HealthNewsDigest.com, call Mike McCurdy: 877-634-9180 or [email protected] We have over 7,000 journalists as subscribers.



Top of Page

HealthNewsDigest.com

Research
Latest Headlines


+ New Statin Guidelines are an Improvement
+ New Gluten-free Ingredient May Cause Allergic Reaction
+ Gene Technique Identifies Hidden Causes of Brain Malformation
+ Some Anti-Inflammatory Drugs Affect More Than Their Targets
+ Medicinal Oil Reduces Debilitating Epileptic Seizures
+ Shopping Stress
+ MU Researcher Develops and Proves Effectiveness of New Drug for Spinal Muscular Atrophy
+ Preschoolers With Special Needs Benefit From Peers’ Strong Language Skills
+ Combination Treatment for Hepatitis C Associated With Favorable Response Among Patients With HIV
+ Is It Love or Lust ? Check Out the Eyes!



Contact Us | Job Listings | Help | Site Map | About Us
Advertising Information | HND Press Release | Submit Information | Disclaimer

Site hosted by Sanchez Productions