Advanced Search
Current and Breaking News for Professionals, Consumers and Media



Click here to learn how to advertise on this site and for ad rates.

Research Author: Staff Editor Last Updated: Jun 17, 2014 - 10:25:10 AM



Boost for Dopamine Packaging Protects Brain in Parkinson’s Model

By Staff Editor
Jun 17, 2014 - 10:20:45 AM



Email Newsletter icon, E-mail Newsletter icon, Email List icon, E-mail List icon Sign up for our Ezine
For Email Marketing you can trust


Email this article
 Printer friendly page

(HealthNewsDigest.com) - Atlanta, GA -Researchers from Emory's Rollins School of Public Health discovered that an increase in the protein that helps store dopamine, a critical brain chemical, led to enhanced dopamine neurotransmission and protection from a Parkinson's disease-related neurotoxin in mice.

Dopamine and related neurotransmitters are stored in small storage packages called vesicles by the vesicular monoamine transporter (VMAT2). When released from these packages dopamine can help regulate movement, pleasure, and emotional response. Low dopamine levels are associated with neurodegenerative diseases such as Parkinson's disease and recent research has shown that VMAT2 function is impaired in people with the disease.

Lead researcher Gary W. Miller, PhD professor and associate dean for research at the Rollins School of Public Health and his team generated transgenic mice with increased levels of VMAT2 and found it led to an increase in dopamine release.  In addition, the group found improved outcomes on anxiety and depressive behaviors, increased movement, and protection from MPTP, the chemical that can cause Parkinson's disease-related damage in the brain.

The complete study is available in the June 17, 2014 edition of Proceedings of the National Academy of Sciences (PNAS).

According to Miller, "This work suggests that enhanced vesicular filling can be sustained over time and may be a viable therapeutic approach for a variety of central nervous system disorders that involve the storage and release of dopamine, serotonin, or norepinephrine."

###

For advertising/promotion on HealthNewsDigest.com

contact Mike McCurdy at 877-634-9180 or [email protected]  We have 7,000 journalists as subscribers.



Top of Page

HealthNewsDigest.com

Research
Latest Headlines


+ New Statin Guidelines are an Improvement
+ New Gluten-free Ingredient May Cause Allergic Reaction
+ Gene Technique Identifies Hidden Causes of Brain Malformation
+ Some Anti-Inflammatory Drugs Affect More Than Their Targets
+ Medicinal Oil Reduces Debilitating Epileptic Seizures
+ Shopping Stress
+ MU Researcher Develops and Proves Effectiveness of New Drug for Spinal Muscular Atrophy
+ Preschoolers With Special Needs Benefit From Peers’ Strong Language Skills
+ Combination Treatment for Hepatitis C Associated With Favorable Response Among Patients With HIV
+ Is It Love or Lust ? Check Out the Eyes!



Contact Us | Job Listings | Help | Site Map | About Us
Advertising Information | HND Press Release | Submit Information | Disclaimer

Site hosted by Sanchez Productions