Advanced Search
Current and Breaking News for Professionals, Consumers and Media

Click here to learn how to advertise on this site and for ad rates.

Patient Issues Author: Staff Editor Last Updated: Sep 7, 2017 - 10:06:33 PM

Morphine Plus Ketamine Works Better Than Morphine Alone

By Staff Editor
Jan 13, 2012 - 10:34:32 AM

Email Newsletter icon, E-mail Newsletter icon, Email List icon, E-mail List icon Sign up for our Ezine
For Email Marketing you can trust

Email this article
 Printer friendly page

( - WASHINGTON-Trauma patients who were given ketamine in addition to morphine prior to arriving at the emergency department had nearly 50 percent better pain management than patients who were given only morphine, according to a study published online yesterday in Annals of Emergency Medicine ("Morphine and Ketamine Is Superior to Morphine Alone for Prehospital Trauma Analgesia: A Randomized Controlled Trial")

"Ketamine plus morphine delivered superior pain relief to trauma patients with moderate to severe pain in the out-of-hospital setting," said lead study author Dr. Paul Jennings of Monash University in Melbourne, Australia. "The addition of ketamine did cause more side effects, but they were minor and there were no serious adverse events reported."

Researchers enrolled 135 patients in the study and randomly assigned them to two groups, one receiving only morphine, one receiving morphine and ketamine. All patients initially received five milligrams of morphine intravenously. Sixty-five patients subsequently received five milligrams of morphine intravenously every 5 minutes until they were pain-free. Seventy patients subsequently received 10 or 20 milligrams of ketamine, followed by 10 milligrams every three minutes.

The average pain score for the ketamine group dropped 5.6 points (out of 10), while the morphine group pain scores dropped only 3.2 points. Of the morphine-only group, 14 percent had side effects, most commonly nausea. Of the morphine plus ketamine group, 39 percent had side effects, most commonly disorientation.

"Supplementing out-of-hospital morphine with low-dose ketamine is an effective strategy to mitigate trauma pain," said Dr. Jennings.

Annals of Emergency Medicine is the peer-reviewed scientific journal for the American College of Emergency Physicians, a national medical society. ACEP is committed to advancing emergency care through continuing education, research, and public education. Headquartered in Dallas, Texas, ACEP has 53 chapters representing each state, as well as Puerto Rico and the District of Columbia. A Government Services Chapter represents emergency physicians employed by military branches and other government agencies. For more information visit

# # #

For advertising and promotion on please contact Mike McCurdy: [email protected] or 877-634-9180 is syndicated worldwide and has over 7,000 journalists as subscribers.

Top of Page

Patient Issues
Latest Headlines

+ Racial Minorities Less Likely to See a Doctor for Psoriasis
+ Video Game Improves Doctors’ Recognition and Triage of Severe Trauma Patients
+ Research Could Pave the Way for Pre-Hospital Treatment for Seriously Injured Patients
+ Medication Errors for Admitted Patients Drop When Pharmacy Staff Take Drug Histories in ER
+ Patients with Post-Traumatic Stress Disorder Respond Differently to Certain Sounds
+ Doctors and Patients Make More Decisions Together
+ Patients, Surgery Means Opioid Dependence
+ Researcher Examines Patient Awareness of Prescription Drug Risks
+ AMA Releases New Research on Physicians’ Patient Mix
+ Accelerate Your Patient Visit Workflow with Online Workflow Forms

Contact Us | Job Listings | Help | Site Map | About Us
Advertising Information | HND Press Release | Submit Information | Disclaimer

Site hosted by Sanchez Productions