Deborah W. Bruner, PhD, RN, FAAN, Woodruff professor of nursing at the Nell Hodgson Woodruff School of Nursing, led the team that evaluated 221 men, 18 years and older with clinical stage II prostate cancer, from 76 medical sites across the United States. Participants were randomly selected to receive either tadalafil or placebo six weeks prior to the start of radiotherapy treatment.
Culminating the three-year evaluation, which included categories such as spontaneous erectile function, overall sexual function and satisfaction, and partner-reported satisfaction, findings showed that tadalafil was not associated with improved overall sexual function or satisfaction. Additionally, partners of men assigned to tadalafil noted no significant effect on their sexual satisfaction.
"The good news is that 20 to 25 percent of the study group experienced erectile dysfunction," explains Bruner, who is also the associate director for cancer outcomes at the Winship Cancer Institute. "This is lower than we expected but still a large number of people in this population receiving radiotherapy prostate cancer treatment. Our findings are significant because they warrant the need to find alternative strategies and dosing to prevent this very common condition."
The complete study titled, "Tadalafil for Prevention of Erectile Dysfunction After Radiotherapy for Prostate Cancer," is available in the April 2, 2014 edition of the Journal of the American Medical Association.
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