Why is this new test significant?
Korley: The high-sensitivity assay is able to measure tenfold lower concentrations of troponin — much smaller amounts than the current assay is able to. It takes some time for the proteins to leave the heart and get into the bloodstream, so this new test can tell us a lot sooner whether you’re having a heart attack or not.
It’s also a lot more reliable: If you measure a value now and you repeat that measurement again with the same blood sample, it doesn’t change very much compared to the old assays where there was a larger amount of analytical change.
Another potential benefit is greater prevention of cardiovascular disease. A recent study in JAMA Cardiology found that people with higher levels of troponin, even without having a heart attack, are more likely to develop heart failure. Your annual physical might one day include a routine check of troponin levels. If you have a big bump, that raises a warning flag.
How do current troponin tests for diagnosing heart attack fall short?
Korley: Up until now, most of the existing assays were only able to accurately measure troponin levels in the blood about six hours after the onset of injury, when the measurements get more reliable. If you had a measurement before six hours and it’s negative, you can’t be confident it’s truly negative. The first test may miss it.
If it’s positive, you’re done; it’s easy. But if it’s negative, we have to wait anywhere between three to six hours and then repeat the test — depending on when a patient’s symptoms started — before we can confidently say we don’t see signs of a heart attack.
How do accuracy levels differ between the two tests?
Korley: About 70 percent of people having a heart attack are going to have a positive result on the first blood draw (using the current troponin test). If it’s a big heart attack, we’re going to see it. Those having smaller heart attacks or those with a lot of blockage may have more delay.
Suffice to say, we’re in the business where 70 percent is not good enough. This new test is a lot higher: About 82 percent of those having a heart attack have elevated troponin levels even if the initial blood test is measured within six hours of onset of symptoms.
Beyond prompting heart attack treatment, how else does greater speed aid the process?
Korley: It’s closely tied to patient satisfaction, but also for the safety of other patients. As emergency physicians, the people we worry about the most are the people in the waiting room who we haven’t yet seen.
A significant proportion of emergency department visits are for chest pain. By being able to reduce the amount of time we spend answering whether a patient has had a heart attack, we’re able to focus a little bit more on other patients and decrease our wait times.
What are the downsides to high-sensitivity troponin testing?
Korley: In the past, very few people had noticeable elevations. Some time ago, we could only measure troponin levels in people having a big heart attack. Now, the assays are so sensitive we can measure it in healthy people. Most people have small amounts of circulating troponin.
With this test, then, we have to understand that elevations may sometimes be acute; some are chronic. For example, if someone has had uncontrolled blood pressure for a long time, that may cause damage to the heart. Therefore, if that person has an elevated troponin level, they might not require hospitalization. What they need is a good primary care doctor who can help them get their blood pressure down. Stress from an infection and injury to the brain can injure the heart as well.
As clinicians, we are going to need to be savvy in interpreting the results and not necessarily think that if someone’s troponin value is high the person is having a heart attack. Institutions have to learn how well the test is operating in their hands — and how best to use it to derive the benefits. The rollout has to be cautious.