The study, appearing in the January 15 issue of JAMA, included 3,398 men and women from 4 race/ethnicity groups; non-Hispanic white, African-American, Hispanic, and Chinese. Participants were 45-84 years of age, free of known CVD at baseline, had CAC greater than 0 on their baseline CT, and were followed up through October 2010.
During a median (midpoint) of 7.6 years of follow-up, there were 175 CHD events and an additional 90 other CVD events for a total of 265 CVD events. Analysis of the data found that CAC volume was positively and independently associated with CHD and CVD risk. At any level of CAC volume, CAC density was inversely and significantly associated with CHD and CVD risk.
"The role of CAC density should be considered when evaluating current CAC scoring systems," the authors write.
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