The most recent data showed that multi-drug resistant Salmonella decreased during the past 10 years and resistance to two important groups of drugs - cephalosporins and fluoroquinolones - remained low in 2012. However, in Salmonella typhi, the germ that causes typhoid fever, resistance to quinolone drugs increased to 68 percent in 2012, raising concerns that one of the common treatments for typhoid fever may not work in many cases.
About 1 in 5 Salmonella Heidelberg infections was resistant to ceftriaxone, a cephalapsorin drug. This is the same Salmonella serotype that has been linked to recent outbreaks associated with poultry. Ceftriaxone resistance is a problem because it makes severe Salmonella infections harder to treat, especially in children.
The data are part of the latest report of the National Antimicrobial Resistance Monitoring System (NARMS), a tri-agency surveillance system that has tracked antibiotic resistance in humans (CDC), retail meats (Food and Drug Administration), and food animals (U.S. Department of Agriculture) since 1996. The report from CDC NARMS compares resistance levels in human samples in 2012 to a baseline period of 2003-2007.
"Our latest data show some progress in reducing resistance among some germs that make people sick but unfortunately we're also seeing greater resistance in some pathogens, like certain types of Salmonella," said Robert Tauxe, M.D., M.P.H, deputy director of CDC's Division of Foodborne, Waterborne, and Environmental Diseases. "Infections with antibiotic-resistant germs are often more severe. These data will help doctors prescribe treatments that work and to help CDC and our public health partners identify and stop outbreaks caused by resistant germs faster and protect people's health."
Among the other findings in the 2012 report:
The report introduces a new method for interpreting Campylobacter data and includes links to online interactive graphs where users can choose an organism and an antibiotic and see the "bug-drug" trends from year-to-year in NARMS.
CDC NARMS monitors antibiotic resistance among clinical isolates of six types of common foodborne germs reported from all 50 states. In 2012, NARMS tested over 5,000 isolates for antibiotic resistance. By comparing results in 2012 with the baseline period of 2003-2007, NARMS provides important information on whether foodborne germs are gaining or losing resistance.
The FY 2015 President's Budget requests funding for CDC to improve early detection and tracking of multidrug resistant Salmonella and other urgent antibiotic resistance threats. The proposed initiative would increase CDC's ability to test drug-resistantSalmonella by 20 times. With a $30 million annual funding level over 5 years, CDC estimates that it could achieve a 25 percent reduction in multidrug resistantSalmonella infections, as well as significant reductions in other resistant infections.
The full 2012 NARMS report is available on the CDC website atwww.cdc.gov/narms/reports/
CDC works 24/7 saving lives and protecting people from health threats to have a more secure nation. Whether these threats are chronic or acute, manmade or natural, human error or deliberate attack, global or domestic, CDC is the U.S. health protection agency.
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