|
|
Current and Breaking News for Professionals, Consumers and Media |
|
|
|
|
|
|
| Current and Breaking News for Professionals, Consumers and Media |
|
|
|
|
|
“This is exciting because the drug (valproic acid) is also in clinical trials as a potential cancer drug and has a known safety profile,” said Zhaoxia Sun, associate professor of genetics and senior author of the paper scheduled to be published online this week in the Proceedings of the National Academy of Sciences. Sun’s lab began searching for chemical compounds that would suppress the effects of one of two genes known to cause the most common form of PKD, which is the fourth leading cause of kidney failure. The screens identified a class of molecules called HDAC inhibitors as potential drug candidates. These inhibitors eliminated the curve tail in zebrafish, a defect associated with the PKD-causing gene. The epilepsy drug valproic acid, marketed under brand names such as Depakote, is also a HDAC inhibitor. So Sun’s collaborator Stefan Somlo, professor of internal medicine and genetics at Yale School of Medicine, used the drug to treat mice with PKD. The team noted that treated mice showed a marked reduction of cysts and improved kidney function. Sun observed that multiple HDAC inhibitors are being developed as anti-cancer drugs and each would be a potential candidate to treat PKD. “Currently there is no directed therapy, but it is a slow progressing disease, which frequently takes decades to develop symptoms,” Sun said. “Therefore, a treatment of even modest efficacy could have significant clinical impact. Other Yale authors of the paper were Ying Cao, Nichole Semanchik, Seung Hun Lee, Paolo Emilio Barbano, and Ronald Coifman. Edward Mallinckrodt Jr. Foundation and the National Institute of Diabetes and Digestive and Kidney Diseases funded the study. Subscribe to our FREE Ezine and be eligible for Health News, discounted products/services and coupons related to your Health. We publish 24/7. HealthNewsDigest.com We videotape Press Conferences, produce SMT's, VNR's, B-rolls, PSA's, - all with distribution: HealthyTelevisionProductions Top of Page 
|
Contact
Us | Job Listings
| Help | Site
Map | About Us
Advertising
Information | HND
Press Release | Submit
Information | Disclaimer
Site hosted by Sanchez Productions
