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(HealthNewsDigest.com) - NEW YORK, June 15, 2012 -- A recent study at Oxford University in England and published in Annals of Neurology, has identified a gene that causes vitamin D deficiency and may also be the cause of multiple sclerosis. The study was partly funded by the National Multiple Sclerosis Society, The Wellcome Trust and the support of science investor, Jeffrey Epstein and The Jeffrey Epstein VI Foundation. Multiple sclerosis is a neurological disease caused by the decay of myelin, the fatty sheath that protects the axons around the brain and spinal cord. Myelin is an essential part of neural communication because it not only protects the nerve circuits but promotes efficient conductivity. Every year, approximately 400,000 people in the United States develop the disease and about 2.5 million people worldwide. Symptoms vary widely, ranging from mild tingling to blindness and paralysis. The cause of myelin damage is still hotly debated: some believe it to be an autoimmune disease while others cite viruses or the environment as the culprit. There is growing evidence however of a correlation between multiple sclerosis and vitamin D deficiency. Epidemiological studies also show that populations closer to the equator and the sun, have far fewer case of multiple sclerosis than populations closer to the north or south poles. Researchers at Oxford University have now taken this premise a step further by showing that vitamin D deficiency and therefore multiple sclerosis could have a genetic cause. The study examined the DNA of a group of people with multiple sclerosis who also have a large number of family members with the disease. All the DNA samples showed a distortion of the CYP27B1 gene which controls vitamin D levels in the body. And in a few rare cases where the DNA showed two copies of the distorted gene, the person was found to have a genetic form of rickets caused by vitamin D deficiency as well as multiple sclerosis. Despite this pivotal link, not all people with vitamin D deficiency develop multiple sclerosis. More research is needed to fully understand why only some people develop multiple sclerosis from vitamin D deficiency and why others don't. However, a distortion of the CYP27B1 gene is increasingly apparent in MS cases and it's possible that the gene generates other, yet undetected, complications that lead to the disease--such as genetically caused rickets. "Although vitamin D deficiency doesn't always cause MS, it unveiled a critical genetic source that could be causing other problems that lead to MS," Jeffrey Epstein asserted, whose foundation, advances science and medical research across the United States. "Even if we don't understand all of the implications of that gene's distortion, research can focus on gene therapy, and that will accelerate a cure." The National Multiple Sclerosis Society which also helped fund the Oxford study provides more than 325 research grants worldwide and training fellowships on a broad range of topics from immunology, nerve tissue repair and myelin biology, clinical trials, rehabilitation, psychosocial issues and health care delivery. www.jeffreyepsteinfoundation.com ### For advertising and promotion on HealthNewsDigest.com please contact Mike McCurdy: tvmike13@HealthNewsDigest.com or 877-634-9180 HealthNewsDigest.com is syndicated worldwide, to thousands of journalists and health-related websites. www.HealthNewsDigest.com Top of Page 
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