Advanced Search
Current and Breaking News for Professionals, Consumers and Media



Click here to learn how to advertise on this site and for ad rates.

Children's Health Author: Staff Editor Last Updated: Dec 3, 2012 - 9:15:54 AM



U-M Study Shows BPA Exposure In Fetal Livers

By Staff Editor
Dec 3, 2012 - 12:15:03 PM



Email Newsletter icon, E-mail Newsletter icon, Email List icon, E-mail List icon Sign up for our Ezine
For Email Marketing you can trust


Email this article
 Printer friendly page

U-M study shows BPA exposure in fetal livers

(HealthNewsDigest.com) - ANN ARBOR-New research from the University of Michigan School of Public Health found BPA, or bisphenol A, in fetal liver tissue, demonstrating that there is considerable exposure to the chemical during pregnancy. 

Researchers also found a proportionately higher concentration of free BPA-as opposed to the conjugated forms modified by the body for elimination-further showing that in fetuses the ability to eliminate the chemical from the body is not the same as in adults.

"The general message from our research is that people have to be cognizant of the fact that the adult body may be able to deal with a particular exposure but a developing fetus may not," said Muna Nahar, doctoral student in the School of Public Health's Department of Environmental Health Sciences and first author on the paper. 

Previous animal studies have associated BPA with breast and prostate cancer, and reproductive and behavioral abnormalities. Some research on effects to human health has tied BPA to cardiovascular disease, miscarriage, decreased semen quality and childhood behavioral issues. The chemical also may impact metabolism, diabetes and obesity, although more studies are required to determine its effects. 

Prior research on BPA-a chemical used in many consumer products, including plastic bottles and metal food and beverage cans-has measured concentrations of the chemical in urine. About 95 percent of those who have been tested in a nationally representative health survey study show some level of BPA, but the research to date had yet to firmly establish the presence of the chemical in tissues. 

Understanding the internal dose is essential to determine adverse effects on health, the researchers say. BPA can reach the body through ingestion, inhalation and by contact with the skin.

Nahar and colleagues Dana Dolinoy of the U-M School of Public Health and Chunyang Liao and Kurunthachalam Kannan of the Wadsworth Center at the New York State Department of Health studied the livers of 50 first- and second-trimester fetuses, using high-performance liquid chromatography and mass spectrometry. They found wide variances in how much BPA was present in livers, with some fetuses showing high levels of exposure.

"The finding of free BPA in fetuses is significant," said Dana Dolinoy, the John G. Searle Assistant Professor of Environmental Health Sciences and senior/corresponding author of the study.

After measuring a three-times-higher concentration of free BPA than the conjugated forms in the fetal livers, the researchers then examined the enzymes responsible for metabolizing the chemical and compared them with those at work in adult male and female livers. 

"Our research shows that the argument that it's so rapidly metabolized is not true in fetuses," Dolinoy said.  

The study appears online in the Journal of Biochemical and Molecular Toxicology, which in early 2013 will publish a special print issue focusing on the National Institute of Environmental Health Sciences Outstanding New Environmental Scientist Award (ONES) projects. Dolinoy was awarded a five-year ONES grant in 2009 for the project titled "In Utero Exposure to Bisphenol A: Effects on the Fetal Epigenome."

Dana Dolinoy: http://www.sph.umich.edu/iscr/faculty/profile.cfm?uniqname=ddolinoy

Muna Nahar: http://research.sph.umich.edu/person.cfm?deptID=2&groupID=32&ownerID=478

School of Public Health: http://www.sph.umich.edu/index.html

View a Risk Bites video that explains BPA: http://youtu.be/219JRH3dEwg
(Risk Bites are short insights into the science of risk, produced by Andrew Maynard at the U-M Risk Science Center.)

Follow us on Twitter: @UMNewsService

###

For advertising and promotion on HealthNewsDigest.com please contact Mike McCurdy: [email protected] or 877-634-9180

HealthNewsDigest.com is syndicated worldwide, to thousands of journalists in all media,  and health-related websites. www.HealthNewsDigest.com



Top of Page

HealthNewsDigest.com

Children's Health
Latest Headlines


+ Selecting, Installing, and Registering Child Safety Seats Has Just Become Easier
+ Easing Back-to-School Jitters
+ Tips On Helping Children Sleep
+ Tips for Disciplining Children
+ Keeping Your Baby Safe During Sleep
+ UT Southwestern Researchers Find New Gene Mutations for Wilms Tumor
+ New Baby Nail Clipper Aims to Make Trimming Easier, Safer for Parents
+ Back-to-School Anxiety: Helping Children Cope
+ The New Terms Every Mom-to-Be Needs To Know
+ How to Keep Babies Healthy and Safe



Contact Us | Job Listings | Help | Site Map | About Us
Advertising Information | HND Press Release | Submit Information | Disclaimer

Site hosted by Sanchez Productions