Advanced Search
Current and Breaking News for Professionals, Consumers and Media



Click here to learn how to advertise on this site and for ad rates.

Cancer Issues Author: Staff Editor Last Updated: Nov 30, 2017 - 12:52:55 PM



Researchers Advance Technique to Detect Ovarian Cancer

By Staff Editor
Nov 30, 2017 - 12:48:33 PM



Email Newsletter icon, E-mail Newsletter icon, Email List icon, E-mail List icon Sign up for our Ezine
For Email Marketing you can trust


Email this article
 Printer friendly page

(HealthNewsDigest.com) - HOUSTON – (Nov. 30, 2017) – Researchers at Rice University and the University of Texas MD Anderson Cancer Center have refined and, for the first time, run in vivo tests of a method that may allow nanotube-based probes to locate specific tumors in the body. Their ability to pinpoint tumors with submillimeter accuracy could eventually improve early detection and treatment of ovarian cancer.

The noninvasive technique relies on single-walled carbon nanotubes that can be optically triggered to emit shortwave infrared light. The Rice lab of chemist Bruce Weisman, a pioneer in the discovery and interpretation of the phenomenon, reported the new results in the American Chemical Society journal ACS Applied Materials and Interfaces.

For this study, the researchers used the technique to pinpoint small concentrations of nanotubes inside rodents. The lab of co-author Dr. Robert Bast Jr., an expert in ovarian cancer and vice president for translational research at MD Anderson, inserted gel-bound carbon nanotubes into the ovaries of rodents to mimic the accumulations that are expected for nanotubes linked to special antibodies that recognize tumor cells. The rodents were then scanned with the Rice lab's custom-built optical device to detect the faint emission signatures of as little as 100 picograms of nanotubes.

The device irradiated the rodents with intense red light from an array of light-emitting diodes and read fluorescent signals with a specialized sensitive detector. Because different types of tissue absorb emissions from the nanotubes differently, the scanner took readings from many locations to triangulate the tumor's exact location, as confirmed by later MRI scans.

Weisman said it should be possible to noninvasively find small ovarian tumors within rodents used for medical research by linking nanotubes to antibody biomarkers and administering the biomarkers intravenously. The biomarkers would accumulate at the tumor site. He said more refined versions of the optical scanner may then be able to locate a tumor within seconds, and further advances may extend the method’s application to human cancer detection. The new results suggested that antibody-nanotube probes could potentially detect tumors with as few as 100 ovarian cancer cells, which could make it a valuable tool for early detection.

Rice graduate student Ching-Wei Lin is lead author of the paper. Co-authors from the Bast group at MD Anderson are researcher Dr. Hailing Yang and senior research assistants Weiqun Mao and Lan Pang. Rice co-authors are chemistry graduate student Stephen Sanchez and Kathleen Beckingham, a professor of biosciences.

The research was supported by the National Science Foundation, the Welch Foundation, the National Institutes of Health, the John S. Dunn Foundation Collaborative Research Award Program, the National Cancer Institute, the Cancer Prevention and Research Institute of Texas, the National Foundation for Cancer Research, the Mossy Foundation, Golfers Against Cancer, the Roberson Endowment and Stuart and Gaye Lynn Zarrow.

###



Top of Page

HealthNewsDigest.com

Cancer Issues
Latest Headlines


+ Need for Early Support Among People with Uveal Melanoma
+ Kansas Mom of Three Among the First in the World to Undergo Latest FDA-Approved Cancer Treatment Therapy (VIDEO)
+ Cancer Diagnosis Helps Mayo Physician Better Understand Patient Fears
+ Cancer Risk Associated With Key Epigenetic Changes Occurring Through Normal Aging Process
+ 5 Novel Genetic Changes Linked to Pancreatic Cancer Risk
+ Precision Cancer Therapy Effective in Both Children and Adults
+ New Therapeutic Gel Shows Promise Against Cancerous Tumors
+ Drug Targeting Mutant Cancer Gene is Highly Effective, Durable
+ Similarities Found in Cancer Initiation in Kidney, Liver, Stomach, Pancreas
+ ‘Local Environment’ Plays Key Role in Breast Cancer Progression



Contact Us | Job Listings | Help | Site Map | About Us
Advertising Information | HND Press Release | Submit Information | Disclaimer

Site hosted by Sanchez Productions