Advanced Search
Current and Breaking News for Professionals, Consumers and Media




Cancer Issues Author: Staff Editor Last Updated: Sep 7, 2017 - 10:06:33 PM



Offering Fertility Preservation Option to Young Boys with Cancer

By Staff Editor
Oct 1, 2014 - 1:55:22 PM



Email Newsletter icon, E-mail Newsletter icon, Email List icon, E-mail List icon Sign up for our Ezine
For Email Marketing you can trust


Email this article
 Printer friendly page

(HealthNewsDigest.com) - WINSTON-SALEM, N.C. - Oct. 1, 2014 -  Wake Forest Baptist Medical Center is one of a few centers in the world - and the only one in North Carolina - offering young boys with cancer the opportunity to participate in a research study focused on fertility preservation and restoration.


The research, conducted by the Medical Center's Wake Forest Institute for Regenerative Medicine (WFIRM) under the direction of Anthony Atala, M.D., institute director, gives boys who have a high risk of becoming sterile the option to "bank" a small piece of testicular tissue prior to treatment.

"The average survival rates for childhood cancer are around 80 percent, but a side effect of some treatments can be permanent sterility," said Thomas W. McLean, M.D., a pediatric cancer specialist, who co-leads the experimental biological bank with Hooman Sadri-Ardekani, M.D., Ph.D., a male infertility specialist at WFIRM. "Preserving or restoring the ability of our patients to one day have children is an important aspect of their treatment."

From the stored tissue, researchers can extract spermatogonial stem cells (SSCs), which are responsible for the continuous production of sperm throughout adult life.

Physicians and scientists hope that when the boys reach adulthood, the cells can be transplanted back into their testicles through a simple injection and they will be able to produce sperm.

"SSC transplantation has not yet been attempted in humans, but has been performed successfully in several species of animals, including monkeys," said Sadri-Ardekani, whodeveloped the first laboratory protocol to isolate and grow human SSCs from small testicular biopsies. 

McLean said a treatment to preserve fertility in boys who are not sexually mature is especially needed because no options currently exist for them. Older boys and men, on the other hand, can bank sperm for future use and women and girls can bank eggs or ovarian tissue. 

SSCs are particularly sensitive to radiation and chemotherapy. Examples of cancers that involve these treatments that have a high risk of infertility are certain leukemias, Hodgkin's disease, brain tumors and bone cancer. 

For the current research study, participants have a small piece of testicular tissue harvested under general anesthesia while they are undergoing another procedure associated with their care, such as putting a catheter in the chest to deliver chemotherapy drugs.

"Because the testicular biopsies do not contain enough SSCs to fully repopulate the testis, we developed a protocol to multiply the original SSCs by sufficient numbers for re-implantation," said Sadri-Ardekani.

The experimental testicular tissue banking was designed under Good Tissue Processing (GTP) practices and is registered by the U.S. Food and Drug Administration and the ICCBBA, an international standards organization, for possible future cell therapy. The tissue is frozen free of charge until patients are at least 18 years old. At that time, it is expected that they will have the opportunity to enter into a separate research study to consider implantation.

"We are pleased that Wake Forest Baptist can offer this option to our young patients at Brenner Children's Hospital," said McLean. "Our hope is that by the time they are adults, these stored cells can be used to restore their fertility."

This project is a collaborative effort of Blood and Marrow Transplantation, the Center for Reproductive Medicine, Pediatric Oncology, Pediatric Urology, Pediatric Surgery and WFIRM. 

###

For advertising/promo rates, please email Mike McCurdy, or call 877-6634-9180. We have over 7,000 journalists as subscribers.



Top of Page

HealthNewsDigest.com

Cancer Issues
Latest Headlines


+ Cancer and Mental Health
+ Immunotherapy Drug Shows Continued Promise in Several Advanced-Stage Cancers
+ Find New Mechanism to Turn on Cancer-Killing T Cells
+ Back to the Trails After Cancer Rehabilitation
+ Breakthrough COVID Infections More Likely in Cancer and Alzheimer’s Patients
+ Consider all Treatment Options for Ovarian Cancer
+ Men Need to Take Melanoma Seriously
+ Melanoma a Higher Risk for Older Veterans
+ Precision Medicine Approach to Metabolic Therapy for Breast Cancer
+ Test for Multiple Myeloma Provides Clues of a Rare, More Deadly Type



Contact Us | Job Listings | Help | Site Map | About Us
Advertising Information | HND Press Release | Submit Information | Disclaimer

Site hosted by Sanchez Productions