From HealthNewsDigest.com

Cancer Issues
New Tool Helps Physicians Estimate Survival for Patients with Cancers That Have Spread to Bone
By
Feb 9, 2018 - 11:29:46 AM

(HealthNewsDigest.com) - A simple three-factor tool can help doctors estimate survival time in patients with long bone metastases (LBMs)—advanced cancer that has spread to the bones of the limbs, reports a study in the February 7, 2018, issue of
The Journal of Bone & Joint Surgery. The journal is published in partnership with Wolters Kluwer. Reliable survival estimates in these cases can help prevent overtreatment and undertreatment.

"This study presents a model to easily stratify patients with symptomatic LBM according to their expected survival," write J.J. Willeumier, MD, of Leiden University Medical Center, the Netherlands, and colleagues from several European institutions. The researchers believe their model can help to select the most appropriate treatment for patients with symptomatic bone metastases.

Model Helps Match Treatment to Expected Survival

Physicians and surgeons are often called upon to estimate survival for patients with advanced cancer to help them maximize the remaining quality of life. Accurate survival estimates are important to avoid overtreatment (putting the patient through treatments that would ultimately not provide much benefit) and undertreatment (not offering treatments that would be beneficial). But data on which to base survival estimates are often sparse, especially for patients with LBMs.

To assess their "easy-to-use prognostic model," Dr. Willeumier and colleagues analyzed 1,520 patients treated for symptomatic LBMs at six Dutch hospitals between 2000 and 2013. The patients' average age was 65; the most common initial (primary) cancer sites were the breast and lung. The main symptoms requiring treatment were painful bone lesions and impending or actual pathologic fractures.

The authors previously identified three independent predictors of survival in patients with spinal metastases and applied them to these patients with LBM:

Depending on their individual combination of these factors, patients could be classified into groups with median survival times of 29.1 months, 10.5 months, 4.6 months, and 2.2 months. The authors created a simple-to-use flowchart for use in estimating survival. The model performed well in predicting the survival category for individual patients based on their actual survival. The model's performance was also validated when applied to a separate group of patients with symptomatic LBMs.

"The simplicity and clarity of the model facilitate and encourage its use in the routine care of patients with LBM, to provide the most appropriate treatment for each individual patient," Dr. Willeumier and coauthors add. They believe their survival estimation tool might become even more useful in the future, with continued advances in tumor classification and individualized cancer therapies.

Click here to read “An Easy-to-Use Prognostic Model for Survival Estimation for Patients with Symptomatic Long Bone Metastases.”

DOI: 10.2106/JBJS.16.01514

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About The Journal of Bone & Joint Surgery

The Journal of Bone & Joint Surgery (JBJS) has been the most valued source of information for orthopaedic surgeons and researchers for over 125 years and is the gold standard in peer-reviewed scientific information in the field. A core journal and essential reading for general as well as specialist orthopaedic surgeons worldwide, The Journal publishes evidence-based research to enhance the quality of care for orthopaedic patients. Standards of excellence and high quality are maintained in everything we do, from the science of the content published to the customer service we provide. JBJS is an independent, non-profit journal.

About Wolters Kluwer

Wolters Kluwer N.V. (AEX: WKL) is a global leader in information services and solutions for professionals in the health, tax and accounting, risk and compliance, finance and legal sectors. We help our customers make critical decisions every day by providing expert solutions that combine deep domain knowledge with specialized technology and services.

Wolters Kluwer reported 2016 annual revenues of €4.3 billion. The company, headquartered in Alphen aan den Rijn, the Netherlands, serves customers in over 180 countries, maintains operations in over 40 countries and employs 19,000 people worldwide.

Wolters Kluwer Health is a leading global provider of information and point of care solutions for the healthcare industry. For more information about our products and the organization, visit http://www.wolterskluwer.com/, follow @WKHealth or @Wolters_Kluwer on Twitter, like us on Facebook, follow us on LinkedIn, or follow WoltersKluwerComms on YouTube.

For more information about Wolters Kluwer’s solutions and organization, visit www.wolterskluwer.com, follow us on TwitterFacebookLinkedIn, and YouTube.

 



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