Advanced Search
Current and Breaking News for Professionals, Consumers and Media



Click here to learn how to advertise on this site and for ad rates.

Cancer Issues Author: Staff Editor Last Updated: Jun 2, 2014 - 11:24:32 AM



Long-term Results Encouraging for Combination Immunotherapy for Advanced Melanoma

By Staff Editor
Jun 2, 2014 - 11:18:55 AM



Email Newsletter icon, E-mail Newsletter icon, Email List icon, E-mail List icon Sign up for our Ezine
For Email Marketing you can trust


Email this article
 Printer friendly page

(HealthNewsDigest.com) - New Haven, Conn.-The first long-term follow-up results from a phase 1b immunotherapy trial combining drugs for advanced melanoma patients has shown encouraging results - long-lasting with high survival rates - researchers report. First author Mario Sznol, M.D., professor of medical oncology at Yale Cancer Center, is presenting the updated data at the 2014 annual conference of the American Society of Clinical Oncology (ASCO) in Chicago.

Sznol, clinical research leader of the melanoma research program at Yale Cancer Center, was the senior author on the original study of combination immunotherapy that was first published in the New England Journal of Medicine and presented at ASCO in 2013. Jedd Wolchok, M.D., of Memorial Sloan Kettering Cancer Center was first author of the earlier study, and senior author of this updated research.

The trial evaluated the safety and activity of the combination regimen of nivolumab (anti-PD-1), an investigational PD-1 immune checkpoint inhibitor, and ipilimumab (anti-CTLA-4; Yervoy), given either concurrently or sequentially, to patients with advanced melanoma whose disease progressed after prior treatment. The one-year overall survival rate was 94% and the two-year rate was 88%.

"The treatment of advanced melanoma has changed dramatically in the last few years, but there continues to be a need to increase the number of patients who experience a long-term survival benefit," Sznol said. "While these are phase 1b data, the duration of response and one- and two-year survival rates observed with the combination regimen of nivolumab and Yervoy are very encouraging and support the rationale for the ongoing, late-stage trials of this combination regimen."

CTLA-4 and PD-1 are targets for cancer immunotherapy because they are shut down the immune system's ability to respond to attack tumors. Antibodies blocking CTLA-4 and PD-1 enable a strong immune response against cancer by removing the brakes from the immune system. Nivolumab targets the PD-1 receptor on the surface of T-cells, and ipilimumab targets CTLA-4 receptors. Both are manufactured by Bristol-Myers Squibb, which sponsored the study with Ono Pharmaceutical Company, Ltd.

Other authors are Harriet Kluger, M.D., Kathleen Reed, Matthew Burke, and Anne Caldwell of Yale School of Medicine and Yale Cancer Center; Margaret Callahan. M.D., Michael Postow, M.D., Naiyer Rizvi, M.D., Alexander Lesokhin, M.D., Neil Segal, M.D., Charlotte Ariyan, M.D., Ruth-Ann Gordon, Stephanie Kronenberg, and Blessing Agunwamba of Memorial Sloan-Kettering Cancer Center; Xiaoling Zhang of Dako North America; Israel Lowy, M.D., Hector David Inzunza, M.D., William Feely, Christine Horak, Quan Hong, Alan Korman, John Wiggington, M.D., and Ashok Gupta, M.D., of Bristol-Myers Squibb; Michael Atkins of Georgetown-Lombardi Comprehensive Cancer Center; and John Kirkwood of the University of Pittsburgh Medical Center.

Yale Cancer Center: http://yalecancercenter.org/index.aspx

Smilow Cancer Hospital at Yale-New Haven: http://www.ynhh.org/smilow-cancer-hospital/default.aspx

###

For advertising/ promotion on HealthNewsDigest.com, call Mike McCurdy at: 877-634-9180, or email at: [email protected] We have over 7,000 journalists as subscribers who can use our content.

 



Top of Page

HealthNewsDigest.com

Cancer Issues
Latest Headlines


+ Aggressive Tumors Silence Genes that Fight Cancer
+ Cancer and Game Theory
+ Pancreatic Surgery Complications Impact Hospital Costs More Than Length of Stay
+ Depressed Men with Prostate Cancer are Diagnosed with Later Stage Disease Don’t Live as Long as Men who are Not Depressed
+ Advances in Treating Children with Cancer: The CWPW Pediatric Solid Tumor Program
+ Breast Cancer—Men Get It Too
+ New Future for Prostate Cancer
+ Low Dose of Targeted Drug Might Improve Cancer-Killing Virus Therapy
+ Targeted Patient Outreach Can Improve Colon Cancer Screening Rates
+ FDA Approves Lymphoseek to Help Determine the Extent of Head and Neck Cancer in the Body



Contact Us | Job Listings | Help | Site Map | About Us
Advertising Information | HND Press Release | Submit Information | Disclaimer

Site hosted by Sanchez Productions