Advanced Search
Current and Breaking News for Professionals, Consumers and Media



Click here to learn how to advertise on this site and for ad rates.

Cancer Issues Author: Staff Editor Last Updated: Oct 12, 2017 - 10:17:20 AM



Esophageal Cancer 'Cell of Origin' Identified

By Staff Editor
Oct 12, 2017 - 10:12:41 AM



Email Newsletter icon, E-mail Newsletter icon, Email List icon, E-mail List icon Sign up for our Ezine
For Email Marketing you can trust


Email this article
 Printer friendly page

(HealthNewsDigest.com) - NEW YORK, NY —
Columbia University Medical Center (CUMC) researchers have identified cells in the upper digestive tract that can give rise to Barrett’s esophagus, a precursor to esophageal cancer. The discovery of this “cell of origin” promises to accelerate the development of more precise screening tools and therapies for Barrett’s esophagus and esophageal adenocarcinoma, the fastest growing form of cancer in the U.S.

The findings, made in mice and in human tissue, were published in today’s online edition of Nature.

In Barrett’s esophagus, some of the tissue in the tube connecting the mouth to the stomach are replaced by intestinal-like tissue, causing heartburn and difficulty swallowing. Most cases of Barrett’s stem from gastroesophageal reflux disease (GERD)—chronic regurgitation of acid from the stomach into the lower esophagus. A small percentage of people with Barrett’s esophagus develop esophageal adenocarcinoma, the most common form of esophageal cancer.

Incidence of esophageal adenocarcinoma has risen by 800 percent over the past four decades. However, there has been little progress in screening and treatment over the same period. If esophageal cancer is not detected early, patients typically survive less than a year after diagnosis.

Researchers have proposed at least five models of Barrett’s esophagus, each based on a different cell type. “However, none of these experimental models mimics all of the characteristics of the condition,” said study leader Jianwen Que, MD, PhD, associate professor of medicine at CUMC. “This led us to believe that there must be another, yet-to-be-discovered, cell of origin for Barrett’s esophagus.”

In the current study, Dr. Que and his colleague Ming Jiang, PhD, an associate research scientist in CUMC’s Department of Medicine and first author of the paper, genetically altered mice to promote the development of Barrett’s esophagus. His team then examined the mice’s gastroesophageal junction tissue for changes. “All of the known cells in this tissue remained the same, but we found a previously unidentified zone populated by unique basal progenitor cells,” he said. Progenitor cells are early descendants of stem cells that can differentiate into one or more specific cell types.

Dr. Que’s team then performed a technique called lineage tracing to determine if these unique basal progenitor cells, tagged with a fluorescent protein, can give rise to Barrett’s esophagus. In the tests, several mouse models were used to show that bile acid reflux or genetic changes promote expansion of these cells, leading to the development of Barrett’s esophagus. The same observations were made in organoids (artificially grown masses of cells that resemble an organ) created from unique basal progenitor cells that were isolated from the gastroesophageal junction in mice and humans.

“Now that we know the cell of origin for Barrett’s esophagus, the next step is to develop therapies that target these cells or the signaling pathways that are activated by acid reflux,” said Dr. Que.

The study is titled, “Transitional basal cells at the squamous-columnar junction generate Barrett’s oesophagus.” The other contributors are: Haiyan Li (Columbia University Medical Center, New York, NY), Yongchun Zhang (CUMC), Ying Yang (CUMC), Rong Lu (CUMC), Kuancan Liu (CUMC and Fuzhou General Hospital, Fuzhou, Fujian, China), Sijie Lin (CUMC and Fuzhou General Hospital), Xiaopeng Lan (Fuzhou General Hospital), Haikun Wang (Chinese Academy of Sciences, Shanghaim, China), Han Wu (Ascendas Genomics Inc., Zhongshan, Guandong, China), Jian Zhu (University of Rochester, Rochester, NY), Zhongren Zhou (University of Rochester), Jianming Xu (Baylor College of Medicine, Houston, TX), Dong-Kee Lee (Baylor College of Medicine), Lanjing Zhang (University Medical Center of Princeton at Plainsboro, Plainsboro, NJ, and Rutgers University, Newark, NJ), Yuan-Cho Lee (CUMC), Jingsong Yuan (CUMC), Julian A. Abrams (CUMC), Timothy G. Wang (CUMC), Antonia R. Sepulveda (CUMC), Qi Wu (Tianjin Haihe Hospital, Tianjin. China), Huaiyong Chen (Tianjin Haihe Hospital), Xin Sun (Tianjin Haihe Hospital), Junjun She (Xi’an Jiaotong University, Xi’an, China), and Xiaoxin Chen (North Carolina Central University, Durham, NC).

The study was supported by grants from the National Institutes of Health (R01DK113144, R01DK100342R01HL132996R01CA112403, and R01CA193455), March of Dimes, Price Family Foundation, the National Key Research and Development Program of China, National Natural Science Foundation of China, the Program for the Top Young Innovative Talents of Fujian Province, and the International Collaborative Project of Fujian Province.

The authors report no financial or other conflicts of interest.

####



Top of Page

HealthNewsDigest.com

Cancer Issues
Latest Headlines


+ Number of Newly Diagnosed Cancer Patients Without Insurance Drops in First Year of ACA
+ Risk for Developing HPV-Related Throat Cancer Low
+ Nerves Drive Prostate Cancer
+ Rare Cancer Linked with Textured Breast Implants May Be Underreported, Misunderstood
+ How UV Rays Trigger Skin Cancer
+ Plant-Based Diet Converts Breast Cancer in Mice From Lethal to Treatable Form
+ Biology of Childhood Brain Tumor Subtypes Offers Clues to Precision Treatments
+ Discover New Blood Test That May Diagnose Breast Cancer
+ Bolstering Fat Cells Offers Potential New Leukemia Treatment
+ 1 in 9, or 11 Million, U.S. Men are Infected with Oral HPV



Contact Us | Job Listings | Help | Site Map | About Us
Advertising Information | HND Press Release | Submit Information | Disclaimer

Site hosted by Sanchez Productions