Advanced Search
Current and Breaking News for Professionals, Consumers and Media



Click here to learn how to advertise on this site and for ad rates.

Cancer Issues Author: Staff Editor Last Updated: Jun 16, 2017 - 11:08:15 AM



Drug Shows Promise in Treating BRCA-related Breast Cancer

By Staff Editor
Jun 16, 2017 - 11:03:36 AM



Email Newsletter icon, E-mail Newsletter icon, Email List icon, E-mail List icon Sign up for our Ezine
For Email Marketing you can trust


Email this article
 Printer friendly page

(HealthNewsDigest.com) - After all 13 breast cancer patients in a first-of-its-kind clinical trial responded positively to a new targeted therapy, MD Anderson researchers are taking the next step toward establishing a potentially new standard of care.

All study subjects experienced significant tumor shrinkage after just two months of treatment with a drug called a PARP inhibitor. Their tumors shrank anywhere from 30 to 98 percent, with a median reduction of 88 percent.

PARPs – short for Poly (ADP-ribose) polymerase – are proteins that can help different types of cells, including cancer cells, repair and survive damaged DNA. Inhibiting PARPs can keep cancer cells from surviving DNA damage and spreading.

“Acknowledging that this is a small study, I can’t think of any drug-based therapy that gives results this consistently strong in only two months,” says Jennifer Litton, M.D., associate professor of Breast Medical Oncology and leader of the study.

Now an extension of the original trial is underway, in which the PARP inhibitor talazoparib is given before any other treatment to newly diagnosed patients who also have BRCA genetic mutations which are associated with 5 to 10 percent of breast cancers and some ovarian cancers. BRCA-related cancers are thought to be vulnerable to PARP inhibitors. Currently, a chemotherapy combination followed by surgery is the frontline therapy.

In the initial trial, patients agreed to delay chemotherapy and first take talazoparib for two months, then proceed to chemotherapy and surgery. In the extension trial, patients are treated only with talazoparib before surgery.

“If the extension study produces strong results similar to those in the first trial,” Litton said, “the next step will be to directly compare talazoparib to chemotherapy in the presurgical, curative setting.”

Chemotherapy may even be delayed or replaced if the extension trial is similarly effective and shows less toxicity than the initial trial, she adds.

PARP inhibitors are approved by the Food and Drug Administration for advanced ovarian cancer, but are not yet approved for breast cancer.

Read more about this study in MD Anderson’s annual report.



Top of Page

HealthNewsDigest.com

Cancer Issues
Latest Headlines


+ An Infallible Hand-Held Probe to Aid Cancer Surgery
+ How Ovarian Cancer Spreads
+ What Stops Chinese Elderly From Using Preventive Care and Personalized Treatments for Cancer?
+ Grape-based Compounds Kill Colon Cancer Stem Cells in Mice
+ HPV Testing Leads to Earlier Detection and Treatment of Cervical Precancer
+ Patient Selection Key to Successful Immunotherapy
+ Underused Cancer Test Could Improve Treatment for Thousands
+ Throat Cancer Symptoms
+ How Mohs Surgery is Used to Fight Skin Cancer
+ Expedited Breast Cancer Treatment (VIDEO)



Contact Us | Job Listings | Help | Site Map | About Us
Advertising Information | HND Press Release | Submit Information | Disclaimer

Site hosted by Sanchez Productions