Advanced Search
Current and Breaking News for Professionals, Consumers and Media



Click here to learn how to advertise on this site and for ad rates.

Alzheimer Issues Author: Staff Editor Last Updated: Dec 4, 2017 - 10:42:43 AM



Lasers Could Lead to Better Understanding of Neurodegenerative Conditions Like Alzheimer’s

By Staff Editor
Dec 4, 2017 - 10:39:47 AM



Email Newsletter icon, E-mail Newsletter icon, Email List icon, E-mail List icon Sign up for our Ezine
For Email Marketing you can trust


Email this article
 Printer friendly page

(HealthNewsDigest.com) - Boulder researchers are embarking on a new project to study the progression of neurodegenerative diseases like Alzheimer's by using a new technique to measure neurons firing deep inside animal brains.

Eventually, the scientists hope, the research could lead to earlier diagnosis and better treatment options.

Led by Ralph Jimenez of JILA – a joint institute of the University of Colorado Boulder and the National Institute for Standards and Technology (NIST) – the research team aims to develop quantum light sources and biological labeling techniques for measuring neural processes in real time.

The effort is funded by a $6.5 million competitive grant from NIST’s Innovations in Measurement Science program. Other project scientists include Marty Stevens and Thomas Gerrits of NIST’s Boulder laboratories as well as Marcus Cicerone at the NIST laboratories in Gaithersburg, Maryland. In addition, the effort will involve CU Boulder postdoctoral students and graduate students from both the physics and the chemistry and biochemistry departments, said Jimenez.

“In order to make progress in this field, scientists need to be able watch neurons when they are performing tasks like learning, memory and perception,” said Jimenez, also an associate adjoint professor in CU Boulder's Department of Chemistry and Biochemistry.

“This new capability could revolutionize the ability of scientists to learn more about conditions like Alzheimer’s and Parkinson’s disease, he said. “The aim is to enable diagnosis of neurodegeneration before it becomes fatal.”

The new laser microscopy technique, which scientists hope can be carried over from mouse to human research, involves shooting pairs of photons, or packets of light, deep into brain tissue. The photons will then be absorbed by mouse neurons that have been genetically engineered to emit a different color of light during the interaction.

The emitted light, which emerges from a focused laser spot microscopic in size, will then be collected and scanned to create a 3-D image of the brain’s inner workings. Jimenez said it will be possible to create “movies” of the process using these packets of light.

Today, researchers using lasers to image neurons in a mouse brain are only able to penetrate a millimeter or so into the brain tissue before the high-power laser light is scattered by tissues, which is a huge obstacle, said Jimenez. The new technique will allow deeper penetration without heating or damaging neurons. Researchers will ultimately be able to access brain regions of mammals where learning and memory occur.

“If we can see how Alzheimer’s happens in real time at the neuron level, for example, scientists can begin thinking about designing drugs or other interventions,” Jimenez said.

“We are looking at this like a ‘moonshot’ project,” he said. “With sufficient funding and momentum, dramatic advances can happen quickly.”



Top of Page

HealthNewsDigest.com

Alzheimer Issues
Latest Headlines


+ Population of Americans with Alzheimer’s Will More Than Double by 2060
+ Experimental Drug Blocks Toxic Ion Flow Linked to Alzheimer’s Disease
+ Lasers Could Lead to Better Understanding of Neurodegenerative Conditions Like Alzheimer’s
+ Hope for Alzheimer’s Disease
+ Benzodiazepines Increase Mortality in Persons with Alzheimer’s Disease
+ Brain Astrocytes Linked to Alzheimer’s Disease
+ 10 Early Signs of Alzheimer's
+ Does Forgetfulness When You’re Young Mean You’ll Get Alzheimer’s Disease? (VIDEO)
+ Biomarker May Predict Early Alzheimer’s Disease
+ How Alzheimer’s Disease Affects Personality (VIDEO)



Contact Us | Job Listings | Help | Site Map | About Us
Advertising Information | HND Press Release | Submit Information | Disclaimer

Site hosted by Sanchez Productions